I had a few builds which were literally invulnerable so long as I paid attention and kept up my skills and movement. These builds had no changes to them, or maybe a small change to damage but none to defenses. These builds have gotten ridiculously destroyed in normal monos after the patch. The same monos they were running pre-patch. Same level, same mods, etc. And I checked monster types, and they were dying to older monster types, not the new poison-centric ones (dying to cold, physical, fire, etc.) Literally the exact same Mono mods and same defenses, and they died repeatedly and FAST.
So, something is off with monster damage, as it shouldn’t be that dramatic. I have to imagine builds with “meh” defenses are even worse, nevermind glass-cannon builds.