As has been said, if we had a magic wand we’d have WASD movement given the sheer amount of work that is required to add that to Last Epoch.
As a player who also has low-level arthritis/raynauds and plays a click-heavy Rogue build, fingerless compression gloves help a ton as do controllers (though I do understand that each person experiences health issues differently so controllers might cause more issues instead of solving them).
It’s also worth looking up gentle hand stretches, I double up moisturising my hands with massaging/stretching which has been helping too 