@Taqhart does a better job of explaining the issue here: [Unable to interact with npcs and objects in town] .
Basically, if you choose “move or attack” as your left click option, you can’t interact with npcs/chests when in town. If you change it back to just “Move” or “Move or Break Distructible” it fixes the issue. His issue has the diagnostics though and all that, I just wanted to put a post out there with more details to the issue, so people aren’t running around trying to figure it out.