This is a known performance related instability problem. I.e. higher settings on older hardware can cause the game to crash.
Based on helping out on the forum for almost 2 years, this performance is about what can be expected from the game right now.
I use a GTX 1060 3GB (about 5-10% faster performance than a rx 570) and I run the game at Very Low settings with a 60fps framerate limit (very important) at 1080p… I can run it at Medium but the game will freeze or have lag spikes regularly… If I do not cap the framerate in-game (not vsync) to 60 or less, then it WILL eventually crash on Medium or higher settings - especially if using a map teleport/changing maps.
Until the devs optimise the game performance, there is very little that you can do about this right now.
Most stable & highest performance settings at 1080p, are Very Low quality. special features disabled or on their lowest setting, 60fps in-game framerate limit (NOT vsync). Streamer mode disabled.
EDIT: The above is assuming that the game files have been verified (Steam), you are using a recent GPU driver installed via a clean installation, your windows is patched properly and that there are no 3rd party apps that could be conflicting with the unity game engine…