…is it possible? If so, I can’t seem to figure it out.
No that functionality is not currently present.
There are some workarounds to achieve that, but they are very complex and need to be done on a item type by item type basis. And I would generally not recommend them anyway.
The best thing you can do is set up the rest of your loot filter in specific enough ways that empty affix slots don’t matter as much.
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