Yeah. The best RNG insanity example is Zizarans death in hardcore SSF league.
Context for non-POE players:
Zizaran is veteran player that plays mostly Hardcore SSF (equivalent to hardcore solo chanllenge in LE). He is famous for dying to stupid shit, (walking to the easily avoidable super slow attack) but he has a lot of BS deaths.
His last character before I quit the 3.16 league was Max Block Gladiator. Character stacks attack + spell bloc, a lot of health and armour (works differently than in LE). He had basically around 80k EHP.
He was attempting (he used this character as boss slayer/carry) the Uber Elder fight iirc (or normal Elder fight). He used Maven influence (an NPC that gives random boosts to the boss and if you defeat it, she captures them and you can later on refight them for good loot).
Elder used one of his stronger attacks. Normally it does 5,4k damage to him, 8.2k with crit hit. Since he has insane recovery, living with 400 HP is not a problem, he gets it back in 4 seconds. Maven however empowered his attack WHILE ELDER WAS OFFSCREEN. Empowered attack does 8.8k damage after the math, finally killing him. In the 100 re-attempts (your HC league character moves to the standard league where you can test what killed you and continue farming) he did not die to that attack. All those attempts have been recorded on livestream.
To have that shit happen you need to : get 1 specific attack with around 800 difference of min-max on special boss, he MUST crit you and Maven must boost the damage (she has like 30 different boosts). Also, Elder must be offscreen to not receive the debuff from one specific skill Zizaran used (Defiance banner - when placed, affected enemies deal 15% less damage to you). Also, you of course need to consider that this happens 1/4th of the time, because he blocks 3/4th of the incoming attacks and spells (and block prevents all damage in POE).