I just lost a staff because I was switching it during a boss fight and accidently held shift while clicking on it. The staff dropped to the floor, a second later I died and my staff is gone. Yes it was my mistake, I shouldn’t switch mid-fight but the same is true for when a valuable item drops and you die before you can pick it up.
I wished for a system like in D4 where valuable items are sent to your stash for pick-up or something like that.