The Smite skill states quite clearly it cannot be cast without a target, but it happens quite frequently that I’d be teleported in the middle of nowhere where there’s no enemy nor destructible object.
Since I keep it on autocast it is quite noticeable when that occurs, especially in any of the outposts.
A few minutes ago something even more bizarre happened: I teleported to Lagon’s Isle and the smite immediately teleported me to a zone way outside any screen boundaries.
This is a screenshot showing the unexplored map and the distance between the teleportation circle and where Smite brought me.