I just did an echo where I had to destroy a venomous spire, but the spire never launched any poison or anything. I could go from my spawn position to the spire and destroy it with no issue, except of course the mobs on the map.
I don’t know what information could be useful for you. I was in the Last Ruin timeline on normal difficulty, the map was a Ruined Shrine. I was playing a Druid in Spriggan form with a Spriggan companion.