I think it may be useful for some people if I describe it in the separate topic. Classic WASD keybindings are not bad, but can be better.
First, I recommend trying ESDF instead of WASD. Main advantage that it adds 2 easy accessible keys — Q and A (and the old Q is W now, while old Shift is Z. You can still use Shift too if you want). Also, bonus minor advantage is that F key on almost all keyboards have that thing which you can feel with your finger without looking at it, so after you moving hand away, it’s easier to get it back, you don’t need to check if your fingers are on the right keys.
About interacting key — for many players it feels bad right now, but it’s actually better this way, because you will not, for example, pick trash loot instead of attacking. Relevant for melee too, but especially for ranged. At the time EGH will add option to use Left-click for both Skill 1 and interacting, you will already feel comfortable with using it on the separate key. I don’t recommend to go back to the same key for interacting and some skill.
Small tip about Mouse middle button (wheel). While two side-buttons are really useful, I don’t like pressing wheel, it takes a bit of time to press it. However, scrolling wheel down is much faster! I like to use scroll down for some skill. Moving finger back to left-clicking takes time, so it’s perfect for skill with cooldown and long enough animation.
I also highly recommend to swap ESC and CAPS LOCK on your keyboard (better even globally, not only for LE). Believe me, it feels so much better when you can press pause easily at any moment, without even moving your hand, just by moving little finger from A to CAPS.