The bigger problem you need to solve is recovering said mana.
Some builds do that easy, others not so much.
A neat little quirk of damage to mana, is that its dealt at a 5:1 ratio.
So if you take 1k damage after all other mitigation, with 25% damage to mana, you will split the pool into 750 and 250, the 250 will go to mana as 50 mana damage and the 750 will go to health.
it gets even better when you consider the helmet also makes 50% of endurance apply to mana as well so with 60%, all damage dealt to mana is 30% reduced. That means in the above example, 1k damage becomes 750 and 250, the 250 is then reduced by 30% to 175, which is then dealt to mana as 35. which is barely anything for builds that can restore mana quickly.
I think the maths is a bit more complicated as those items/nodes usually say that mana only shields a certain amount of health (& I’ve never been arsed to do the maths), but broadly yes.