Haven’t tested all the nodes yet but for example here are the behaviour of two of them: Plague of Eyes (gives flat dmg per INT) and Concecrated Rot (+25% MORE dmg).
Without any of these nodes my dps is 672
Taking the Concecrated Rot - the dps goes to 723 (+51) that is definitely not a +25% more
Now lets do the same but with Plague of Eyes picked. The dps is 1209
Taking the Concecrated Rot - the dps goes to 1260 (and again +51). So the damage from Plague of Eyes isn’t affected by Concecrated Rot at all
As you see actual result isn’t even close to expected one.