Using the Hammer Throw skill against Venom Weavers (found in i.e. The Lost Refuge) is useless because the hammers will just go through them most of the time without doing any damage.
Even worse are the Voidwing Nests (found in i.e. The Shattered Valley). Those things can’t be hit at all. I have to switch to a different skill to be able to kill them.
I’m not using Orbit or Chain or anything like that. Just throwing the hammers regularly.