What about non-rare runes and glyphs and shards? This stuff is essentially currency and it all gets picked up anyway. Have it be an option that is off by default and turned on in the options.
You’d still have to click the ascendance and despair etc…but the rest should be picked up when you walk over it. Unlike most other items, there isn’t a decision whether it can be useful like there is with gear…it is simply useful.
Gold is already auto pickup and shards/glyphs/runes are AoE manual pickup.
Also auto picked up loot should automatically store itself in the crafting inventory if you have auto pickups enabled for runes/glyphs/shards.